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Galatasaray Spor Kulübü (Turkish pronunciation: [ɡaɫatasaˈɾaj ˈspoɾ kulyˈby], Galatasaray Sports Club), also known as Galatasaray AŞ in UEFA competitions,[4] is a Turkish professional football club based on the European side of the city of Istanbul. It is the association football branch of the larger Galatasaray Sports Club of the same name, itself a part of the Galatasaray Community Cooperation Committee which includes Galatasaray High School where the football club was founded in October 1905 consisting entirely of student members. The team traditionally play in dark shades of red and yellow at home, with the shirts split down the middle between the two colours. Galatasaray is the most successful Turkish football club in history.


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At first, the colours of Galatasaray were red and white. These are the colours in the modern Turkish flag. The Turkish Republic, however, was not founded at that time. Therefore, this decision caused the repressive administration of the day to feel uncomfortable and the administration subsequently pressured the footballers. For this reason, on December 26, 1906, the colors were changed to yellow and black.[40] The eight-piece halved design kit was ordered from the Sports Outfitter William Shillcock based in Birmingham, United Kingdom.[41] After a heavy 0-5 loss to Baltalimanı in a friendly match the new colours yellow and black were counted as inauspicious.

Although AL amyloidosis remains an often incurable disease, much progress has been made in the last 25 years, and important aspects of clinical care for AL amyloidosis patients are guided by evidence-based treatment recommendations. Consensus criteria have been developed and validated for organ involvement, cardiac and renal staging, and hematologic, cardiac, and renal responses. These criteria are widely used in both the clinical and research settings (Table 3).22,23,33 Hematologic and cardiac responses are associated with prolonged survival, and renal responses are associated with longer renal survival (ie, freedom from progression to end-stage renal disease leading to hemodialysis).32 Stopping production of the pathologic FLC translates into significant benefit for most patients, excluding those with advanced cardiac or renal dysfunction.22,32-34

In the late 20th century, melphalan-based therapies dominated the treatment landscape, and high-dose intravenous melphalan followed by autologous hematopoietic stem cell transplantation (SCT) took center stage for eligible patients. These new treatments demonstrated high rates of hematologic remission, reversal of organ dysfunction, and survival benefit without the risks of myelodysplasia and secondary acute myelogenous leukemia typically associated with oral melphalan-based therapies.39,40

Although these gains were encouraging, SCT in this era was associated with unacceptably high procedure-related mortality, particularly in patients with cardiac involvement.39 This led to the era of risk-adapted melphalan dosing with SCT, a novel concept in which the dose of intravenous melphalan was attenuated based on age and organ involvement in order to reduce the treatment-related mortality. Using this system, melphalan was dosed from 100 to 200 mg/m2 based on age, renal function, and cardiac involvement. This approach, with refined patient selection and treatment criteria, reduced treatment-related mortality to less than 5% in high-volume centers.41,42 Risk-adapted melphalan with SCT has redefined the role of SCT as a safe and effective procedure for AL amyloidosis patients, although only 30% of patients are currently eligible for this approach at diagnosis.

By the turn of the century, it was obvious that SCT patients who achieved a complete hematologic response had improved overall survival compared with those who did not (see Figure 2 online at At this time, complete hematologic response was scored by serum and urine immunofixation and marrow-based criteria, because the FLC assay was not yet in clinical use. The benefit of achieving a complete hematologic response with SCT was confirmed by a large single-center retrospective analysis just over a decade later (see Figure 3 online at The complete response rate (immunofixation-based) with SCT is approximately 35%, and those with a complete response have a longer overall survival than those without (13.2 vs 5.9 years, respectively).44 It was also clear that risk-adapted melphalan dosing at 140 mg/m2 or less was associated with a lower complete response rate than melphalan at 200 mg/m2, setting the stage for post-SCT consolidation studies.

Lenalidomide is associated with a 41% hematologic response rate and pomalidomide is associated with a 48% hematologic response rate in patients previously treated with alkylators, bortezomib, and thalidomide. Both lenalidomide and pomalidomide had a low incidence of complete responses (21% and 1%, respectively).62,63 A higher induction dose (4 mg/day) of pomalidomide combined with dexamethasone induces a higher rate of hematologic response (67%) in patients previously exposed to alkylators, other IMiDs, and proteasome inhibitors. However, the cost of this higher response rate is substantial toxicity (67% grade 3 or 4 adverse events leading to treatment discontinuation in 18%) and significant elevation of NT-proBNP.64 More recently, preliminary data of a phase 2a trial testing the combination of bendamustine and dexamethasone in relapsed or refractory patients has shown a 45% hematologic response rate, including a 9% complete response rate.65 For relapsed and refractory disease that is resistant to bortezomib-based regimens, other treatment options include IMiD-based therapy, MDex, or participation in clinical trials.

33. Palladini G, Dispenzieri A, Gertz MA, et al. New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes. J Clin Oncol. 2012;30(36):4541-4549.

There are four major blood types: A, B, O, and AB. The types are based on substances on the surface of the blood cells. Another blood type is called Rh. Rh factor is a protein on red blood cells. Most people are Rh-positive; they have Rh factor. Rh-negative people don't have it. Rh factor is inherited through genes.

Close of Trading Times. Although both the NAV and the daily market price of the Fund are generally calculated based on prices at the closing time of the exchange (generally 4:00 p.m. eastern time), slight differences in this timing may cause discrepancies.

Community based disaster risk reduction approach focuses on engaging communities in building their resiliency to disasters. This approach aims to increase community awareness and ownership of Disaster Risk Reduction Initiatives. Importantly these initiatives need to be incorporated in the planning stages, at the local level and focus on strengthening local capacity to mitigate, prepare and respond to disasters.

The available human studies published up to October 30, 2019, were searched in different databases. Case-control, cohort, and cross-sectional studies were retrieved. Papers published in English or those with an English abstract were included. The risk of bias for each included study was assessed based on the Newcastle-Ottawa Scale (NOS). We then categorized the effects of opium on cardiovascular problems along with its probable underlying mechanisms of action.

Data were extracted using a pre-defined checklist and were assessed by two independent reviewers. The data consisted of the date and place of the study, type of study, sample size and sampling method, information about the participants, the definition of exposure and outcome, route and amount of exposure, age, and gender of the participants, methods of assessment, confounding variables, and the main findings of each study with principal measures (e.g., risk ratio, difference in means, etc.). The risk of bias for each included study was assessed based on the Newcastle-Ottawa Scale (NOS). Studies with a score of 5 or more were considered as high-quality. None of the articles meeting our inclusion criteria were excluded. Finally, we tried to categorize the effects of opium on cardiovascular problems along with identifying its probable underlying mechanisms of action (Fig. 2).

The test is designed to provide you and your healthcare provider (HCP) with actionable decision-making information to reduce your risk of negative COVID-19 related health outcomes based on your unique 3D genetic immune profile.

It is directly linked to your sense of self. This energy center is associated with your self-esteem, sense of purpose, personal identity, individual will, digestion, and metabolism, says Stephanie Snyder, a yoga teacher based in San Francisco. When consciousness moves freely in this center, you are empowered by transformative energy.

Compared to dōjutsu which are almost exclusively passed down through clans, nature transformation kekkei genkai seem to appear in individuals with no known relation. Lava Release, a combination of fire and earth-based chakra, has appeared in ninja from Kirigakure, Iwagakure, and Kumogakure.

Ice Release (氷遁, Hyōton) or Ice Style is the combined nature transformation kekkei genkai of the Yuki clan. It allows the user to freely create and manipulate ice by simultaneously combining wind and water-based chakra. When the user releases their chakra, the surrounding vicinity becomes cold enough to cause snow to fall. The ice Haku creates is also extremely resistant to fire-based attacks, only melting slightly when coming into contact with Sasuke's flames.

Magnet Release (磁遁, Jiton) or Magnet Style is a combined nature transformation kekkei genkai suggested to be made up of techniques that mix wind and earth-based chakra to create magnetic forces in different properties and usages. Various shinobi of Sunagakure, Kumogakure and Ishigakure have possessed this kekkei genkai 041b061a72


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